Physician-Led Telehealth
Real Doctors. Real Results. A Healthier You.
Board-certified physician care, delivered to your door.
Lose Weight with GLP-1 Therapy
Doctor-prescribed semaglutide or tirzepatide, delivered to your door in days. No clinic visits. No hidden fees.
Our Difference
What Makes RxSpan MD Different
Founded and Led by a Physician
RxSpan MD was founded and is led by a board-certified surgeon — not investors or business executives. Medicine, not marketing, drives every decision we make.
Real Medical Oversight
Your care is directed by licensed U.S. physicians. Every request is reviewed by a real clinician before any prescription is approved — no shortcuts, no rubber-stamping.
Certified and Verified
RxSpan MD is LegitScript-certified, meeting rigorous national standards for safety, legality, and transparency in telehealth and online pharmacy care.
Vetted, Licensed Pharmacies
We work only with licensed U.S. pharmacies that we have carefully vetted, so your medication is dispensed safely and meets strict quality standards.
Weight Loss Calculator
How much weight can you lose?
GLP-1 medications help patients lose 15–22% of their body weight on average. Enter your current weight to see your potential results.
Your current weight: 200 lbs
You could lose up to
44 lbs
reaching your goal weight of 156 lbs
*Individual results vary. These estimates reflect average results reported in clinical trials of FDA-approved GLP-1 medications; compounded formulations have not been individually studied for weight-loss efficacy. This is not a guarantee of your results — talk to your provider about what's realistic for you.
Learn More
Understanding your options
Semaglutide
Hover to learn moreSemaglutide
Semaglutide is a medication in a class called GLP-1 receptor agonists. It mimics a natural gut hormone (GLP-1) that the body releases after eating, which helps regulate blood sugar and appetite. At RxSpan MD, semaglutide is offered as a compounded medication in both an injectable and an oral (capsule) form.
About compounded medications. Compounded semaglutide is not FDA-approved. The FDA does not review compounded medications for safety, effectiveness, or quality. Compounded medications are prepared by a state-licensed pharmacy based on an individual prescription, and are provided only when a licensed provider determines they are appropriate for you.
Learn more →
Tirzepatide
Hover to learn moreTirzepatide
Tirzepatide is a medication that activates two natural gut-hormone pathways at once — GIP and GLP-1 (a "dual receptor agonist"). Both hormones help regulate blood sugar, digestion, and appetite. At RxSpan MD, tirzepatide is offered as a compounded medication in injectable and oral (capsule) forms.
About compounded medications. Compounded tirzepatide is not FDA-approved. The FDA does not review compounded medications for safety, effectiveness, or quality. Compounded medications are prepared by a state-licensed pharmacy based on an individual prescription, and are provided only when a licensed provider determines they are appropriate for you.
Learn more →
Wegovy
Hover to learn moreWegovy
Wegovy is a brand-name, FDA-approved prescription medicine whose active ingredient is semaglutide, a GLP-1 receptor agonist. Wegovy is approved for chronic weight management in eligible adults and, per updated labeling, additional uses such as cardiovascular risk reduction.
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Ozempic
Hover to learn moreOzempic
Ozempic is a brand-name, FDA-approved prescription medicine whose active ingredient is semaglutide, a GLP-1 receptor agonist. Ozempic is FDA-approved to treat type 2 diabetes (and to reduce certain cardiovascular risks in adults with type 2 diabetes and known heart disease). It is sometimes prescribed "off-label" by providers for other purposes; weight management is not an FDA-approved use of Ozempic.
Learn more →
Zepbound
Hover to learn moreZepbound
Zepbound is a brand-name, FDA-approved prescription medicine whose active ingredient is tirzepatide, a dual GIP/GLP-1 receptor agonist. Zepbound is approved for chronic weight management in eligible adults.
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Oral Semaglutide
Hover to learn moreOral Semaglutide
Semaglutide is a medication in a class called GLP-1 receptor agonists. It mimics a natural gut hormone (GLP-1) that the body releases after eating, which helps regulate blood sugar and appetite. At RxSpan MD, semaglutide is offered as a compounded medication in both an injectable and an oral (capsule) form.
About compounded medications. Compounded semaglutide is not FDA-approved. The FDA does not review compounded medications for safety, effectiveness, or quality. Compounded medications are prepared by a state-licensed pharmacy based on an individual prescription, and are provided only when a licensed provider determines they are appropriate for you.
Learn more →
Oral Tirzepatide
Hover to learn moreOral Tirzepatide
Tirzepatide is a medication that activates two natural gut-hormone pathways at once — GIP and GLP-1 (a "dual receptor agonist"). Both hormones help regulate blood sugar, digestion, and appetite. At RxSpan MD, tirzepatide is offered as a compounded medication in injectable and oral (capsule) forms.
About compounded medications. Compounded tirzepatide is not FDA-approved. The FDA does not review compounded medications for safety, effectiveness, or quality. Compounded medications are prepared by a state-licensed pharmacy based on an individual prescription, and are provided only when a licensed provider determines they are appropriate for you.
Learn more →This information is provided for general educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. It is not complete prescribing information. Whether any medication is appropriate for you is determined by a licensed provider based on your individual health history. Always talk to your RxSpan MD provider about the risks, benefits, and full prescribing information before starting or changing any treatment.
Compare
How the options stack up
| Semaglutide Capsule | Tirzepatide Capsule | Semaglutide Injection | Tirzepatide Injection | Ozempic | Wegovy | Zepbound | |
|---|---|---|---|---|---|---|---|
| Compounded or branded ¹ | Compounded | Compounded | Compounded | Compounded | Brand | Brand | Brand |
| Form | Oral | Oral | Injection | Injection | Injection | Injection | Injection |
| Active ingredient | Semaglutide | Tirzepatide | Semaglutide | Tirzepatide | Semaglutide | Semaglutide | Tirzepatide |
| Other ingredients | Vitamin B12 | Vitamin B12 | Vitamin B12 | Vitamin B12 | — | — | — |
| Weight loss ² | + | + | ++ | +++ | ++ | ++ | ++++ |
| Cost ³ | $ | $$ | $ | $$ | $$$$ | $$$$$ | $$$ |
Weight loss: more + = greater average weight loss. Cost: more $ = higher typical cost.
This page is an educational evidence synthesis reflecting Dr. John Diaz's professional interpretation of the published literature. It is not a substitute for individualized medical advice, current product labeling, or a review of contraindications and risks. Because formulations and regulatory status change, information is subject to update. Talk to your RxSpan MD provider about what is appropriate for you.
Patient Stories
What our patients are saying
"The entire process was quick, easy, and very convenient. I loved being able to do everything from the comfort of my home — no traffic, no waiting rooms, no time away from work. The whole experience was smooth and reassuring."
Maria A.
Weight Loss
"Not only am I paying less for the exact same medication, but the entire process has been incredibly easy. Everyone I've interacted with has been friendly, knowledgeable, and genuinely helpful. Making the switch was one of the best decisions I've made."
Patty G.
Weight Loss
"One of my favorite parts has been having a real clinician available throughout the process. It's reassuring to know there's someone you can reach out to who genuinely wants to help. Everything was explained clearly from start to finish, and I've felt supported every step of the way."
Savannah A.
Weight Loss
Why RxSpan MD
Care without the compromises
Physician-Reviewed Treatment Plans
Every plan is reviewed and approved by a licensed physician.
Unlimited 24/7 Support
Unlimited appointments and messaging with your care team, anytime.
No Hidden Fees
Transparent pricing — what you see is what you pay.
Free Expedited Delivery
Fast, free shipping straight to your door.
Trusted By
Footnotes
¹ About compounded medications. Compounded medications are prepared by a state-licensed pharmacy based on an individual prescription. They are not FDA-approved, and the FDA does not review compounded drugs for safety, effectiveness, or quality before they are marketed.
² About the weight-loss ratings — please read. These ratings reflect the studied performance of each active ingredient (semaglutide or tirzepatide) in clinical trials of FDA-approved products, based on Dr. Diaz's interpretation of the published evidence cited below. They are general, relative indicators — not guarantees, and not individual predictions; individual results vary widely. Compounded products have not been studied for product-specific weight-loss effectiveness, and their results should not be assumed to match those of the approved medications. A rating shown for a compounded product reflects its active ingredient's studied performance, not proof that the compounded product achieves the same result.
³ Cost is a general relative indicator of typical cost and may vary.
- Ozempic and Wegovy both contain semaglutide; Zepbound contains tirzepatide.
- In the head-to-head SURMOUNT-5 trial, tirzepatide produced 20.2% mean weight loss versus 13.7% with standard-dose Wegovy at 72 weeks — a 6.5-percentage-point difference [1].
- The pivotal oral semaglutide product is a specially engineered tablet — not a generic capsule. There is no FDA-approved oral tirzepatide, and compounded capsules cannot be assumed to reproduce the results of approved formulations [9][11].